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KMID : 0358320110520040247
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Korean Journal of Urology
2011 Volume.52 No. 4 p.247 ~ p.252
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Relationship between the Glutathione-S-Transferase P1,M1, and T1 Genotypes and Prostate Cancer Risk in Korean Subjects
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Kwon Dong-Deuk
Lee Jea-Whan
Han Dong-Youp
Seo Il-Young
Park Seung-Chel
Jeong Hee-Jong
Yang Yun-Sik
Chae Soo-Cheon
Na Kyung-Sook
Kim Joung-Joong
Rim Joung-Sik
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Abstract
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Purpose: The glutathione-S-transferase (GST)P1,GSTM1, and GSTT1 genotypes have been associated with an increased risk of prostate, bladder, and lung cancers. The aim of this study was to investigate the association between the GSTP1,GSTM1, and GSTT1 genotypes and the risk of prostate cancer in Korean men.
Materials and Methods: The study group consisted of 166 patients with histologically confirmed prostate cancer. The control group consisted of 327 healthy, cancer-free individuals. The diagnosis of prostate cancer was made by transrectal ultrasound-guided biopsy. Patients with prostatic adenocarcinoma were divided into organ-confined (≤pT2) and non-organ-confined (≥pT3) subgroups. The histological grades were subdivided according to the Gleason score. The GSTP1,GSTM1, and GSTT1 genotypes were determined by using polymerase chain reaction-based methods. The relationship among GSTP1,GSTM1, and GSTT1 polymorphisms and prostate cancer in a case-control study was investigated.
Results: The frequency of the GSTM1 null genotype in the prostate cancer group (54.2%) was higher than in the control group (odds ratio=1.53, 95% confidence interval=1.20-1.96). The comparison of the GSTP1,GSTM1, and GSTT1 genotypes and cancer prognostic factors, such as staging and grading, showed no statistical significance.
Conclusions: An increased risk for prostate cancer may be associated with the GSTM1 null genotype in Korean men, but no association was found with the GSTT1 or GSTP1 genotypes.
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KEYWORD
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Glutathione S-transferase M1, Glutathione S-transferase P1, Glutathione S-transferase T1, Prostatic neoplasms
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